Aspects

Aspects are optional perks that can be equipped at the start of a run. They make the run significantly easier at the cost of preventing the player from unlocking new Boss Stem Cells or flawless boss achievements while the aspect is equipped. They are provided by the Doctor in the starting area of the Prisoners' Quarters, but only one can be chosen per run.

The first three aspects are unlocked after the introductory runs are completed. To unlock more aspects, one must simply die (assist mode disables the unlocks). For every death, a new aspect is unlocked.