Machete and Pistol

The  is a melee weapon with a three part combo.

Location
In the Prisoners' Quarters, there is a chance for a lore room to spawn with an altar. Examining this altar will drop this item. Upon doing so, player will be cursed with a one-kill curse. Picking the item up will instantly unlock it.
 * "So menacing! Should I really search it?"
 * "Oh, it's not like it's cursed or anything."

Trivia

 * This weapon is based on weapons from the game Curse of the Dead Gods.