Time, Killstreak & No-Hit Doors

Timed doors appear in most biomes. If a timed door is not reached and opened within a set amount of time in a run, it will be locked and unopenable. Time spent in the beginning area of The Prisoners' Cell, the Collector's Room and in shops or treasure rooms does not count towards timed doors. Behind each door are some gems and jewels, which turn into gold when picked up, as well as some cells. Some timed doors also contain Scrolls of Power and/or a blueprint.

Times for each biome
(* This door is actually located in the Collector's room after the Black Bridge)