Boss Stem Cells

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Boss Stem Cells (or simply Boss Cells) are permanent items that increase the difficulty of the game when active. The first one is acquired by beating the Hand of the King with no Boss Stem Cells active, the second by beating him with one active, and so on. However, the fifth Boss Stem Cell is obtained by beating the Giant with four active.

Boss Stem Cells can be injected and removed at the start of the game in the Tube. Each one makes the game significantly harder by increasing enemy tier, density, variety, and limiting healing options. On the other hand, higher difficulty levels also increase cells dropped from enemies and the level of the Legendary Forge, and allow access to new blueprints and bonus doors scattered through the levels, as well as some ones dropped by enemies exclusive to high BSCs. The doors show the number of Boss Stem Cells required to enter and shine blue if enough are currently active. The fifth Boss Cell is special in that it doesn't modify anything compared to the fourth until the Throne Room, where it grants access to a secret biome, the Astrolab, and the hidden final boss of the game in the Observatory.

Modifiers[edit | edit source]

# of Boss Stem Cells Modifiers
Boss Stem Cell Icon.png
- BSC 1.png Hard difficulty

- Broken flask 3.png Health fountains are only available every other level and Passages without them will instead give a flask recharge. Extra ones can also be purchased from food shops.

+ Advanced Forge Icon.png Improves the level of the Legendary Forge by allowing you to increase the frequency of + and ++ items up to 100%

+ Unlocks a door in Prison Depths that goes to the Ancient Sewers

+ Unlocks a door in Corrupted Prison that goes to the Ramparts

+ Allows you to collect the next Boss Stem Cell

+ Bosses skip their first phase

2 Boss Cells.png
- BSC 2.png Very Hard difficulty

- Broken flask 4.png Removes all health fountains, but gives one flask recharge within Passages. Extra ones can also be purchased from food shops.

+ Advanced Forge Icon.png Improves the level of the Legendary Forge by allowing you to increase the frequency of S items up to 25%

+ Cell multiplier 1.png Multiplies the amount of dropped cells by 2 (effect also applies to cells found in containers)

+ Unlocks a door in Slumbering Sanctuary that goes to the Cavern

+ Unlocks a door in Forgotten Sepulcher that goes to Guardian's Haven

+ Allows you to collect the next Boss Stem Cell

+ Bosses skip their first phase

3 Boss Cells.png
- BSC 3.png Expert difficulty

- Broken flask 4.png Free flask recharges now only appear after the first boss and before the second. Extra ones can also be purchased from food shops.

+ Advanced Forge Icon.png Improves the level of the Legendary Forge by allowing you to increase the frequency of S items up to 50%

+ Cell multiplier 2.png Multiplies the amount of dropped cells by 2 (effect also applies to cells found in containers)

+ Scroll Fragments.png Allows you to collect Scroll Fragments

+ EpicPower.png Legendary items and colorless items are improved (Adds +3 to gear power of Legendary items).

+ Unlocks a door in Ramparts that goes to the Insufferable Crypt

+ Allows you to collect the next Boss Stem Cell

+ Bosses skip their first phase

4 Boss Cells.png
- BSC 4.png Nightmare difficulty

+Increases detection range of mobs and gives most of them the ability to teleport next to your position.

- Broken flask 4.png Extra flask recharges can only be purchased from food shops.

+ Advanced Forge Icon.png Improves the level of the Legendary Forge by allowing you to increase the frequency of S items up to 100%

+ Cell multiplier 3.png Multiplies the amount of dropped cells by 3 (effect also applies to cells found in containers)

+ Scroll Fragments.png Allows you to collect more Scroll Fragments

+ EpicPower.png Legendary items and colorless items are improved.

+ Allows you to collect the next Boss Stem Cell from The Giant

+ Bosses skip their first phase

5 Boss Cells.png
- BSC 5.png Hell difficulty

- Increases detection range of mobs and gives most of them the ability to teleport next to your position.

- Broken flask 4.png Extra flask recharges can only be purchased from food shops.

+ Malaise Icon.png Malaise is activated.

See the main article for information about malaise.

+ Advanced Forge Icon.png Improves the level of the Legendary Forge by allowing you to increase the frequency of S items up to 100%

+ Cell multiplier 3.png Multiplies the amount of dropped cells by 3 (effect also applies to cells found in containers)

+ Scroll Fragments.png Allows you to collect more Scroll Fragments

+ EpicPower.png Legendary items and colorless items are improved.

+ Gives access to the Astrolab and the Observatory (Rise of the Giant DLC content). Entrance to The Astrolab is located at the end of Throne Room.

+ Bosses skip their first phase

+ The Collector's Intern replaces the Collector in Passages.

Trivia[edit | edit source]

  • When Boss Stem Cells, then named Boss Runes, were added in the v0.5.3 patch of the Foundry Update, they could all be obtained on 0 BSC difficulty and each was dropped by a different boss.

History[edit | edit source]

  • 0.5: Introduced.
  • 1.2: Introduced 5 BSC difficulty.
  • 1.9: Removed Legendary item improvements from 3+ BSC that added one stat of each color.
  • 2.3: Adjusted BSC difficulty curve:
    • 2 BSC now grants a flask recharge in every Passage.
    • 3 BSC now grants a flask recharge before the first boss and after the second boss.
    • 4 BSC no longer has the Malaise mechanic.

Gallery[edit | edit source]

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