For Brutality builds, it is possible to back it up with Vampirism and the Recovery mutation to compensate for any mistakes made while the skill is active.
Beware that some damage sources have a specified limit which will ignore the skill's negative attribute, such as being hit by traps while Masochist is active.
Corrupted Power is best used for burst damage. As a trade-off, the player needs to avoid attacks to the best of their abilities in order to take maximum advantage of the skill.
It is ill-advised to use weapons such as Blood Sword, Alchemic Carbine and Hokuto's Bow with it since the skill does not affect damage from negative status effects such as bleeding, poisoning, and Hokuto's Mark.