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Mutations, introduced in the Foundry Update (currently in the Beta branch as of December 21, 2017), are passive modifiers which replace Stat-based secondary effects from the Brutal Update. They can be obtained between levels from the NPC that formerly manned small shops holding only two Gear items.

Most mutations are not available initially - to unlock them for future selection, one must first bring their blueprints to the Collector, then spend the requisite amounts of cells.

Mechanics[]

The player can only benefit from a certain number of mutations at once. Each area cleared in a run allows the player to use one more mutation up to a hard limit of 3 mutations. However, the player can choose to spend gold between levels (cost starts at 2500 and scales with loot level up to 9600 before the Clock Room) to remove all current mutations, allowing for a new set of mutations to be chosen to replace the old set.

Most mutations are associated with a specific stat (Brutality, Tactics or Survival), scaling their benefits based on their current levels. Specifically, base damage and healing magnitudes for these mutations are multiplied by (1.15^(n-1)), where n is the current level of the appropriate stat, and rounded to produce the final effect magnitudes (e.g. if a Brutality-scaling mutation provides 30 base extra DPS and the player's Brutality level is at 2, the final extra DPS is (30 * (1.15^(2-1))) = (30 * 1.15) = 34.5 ~= 35). General mutations, however, have fixed benefits which are not affected by the player's stat levels, and the cooldown-reduction mutation has its own unique scaling with Tactics.

List of Mutations[]

Brutality Mutations[]

Name Image Description Base Effects Blueprint Acquisition Method Unlock Cost
Flow About +X DPS for 2 seconds after killing an enemy. 35 DPS N/A (Always available) N/A
Vengeance About +X DPS for 7 seconds after taking damage. 200 DPS The Assassin (5th kill) 50 Cells
Melee About +X DPS while there are at least 2 enemies nearby. 60 DPS Incomplete One (3rd kill) 50 Cells
Sadism About +X DPS while a nearby enemy is suffering from bleeding, poison or burning. 30 DPS Spiker (100% chance) 50 Cells
Corrupted Healing Your flasks only restore 30% of max health, but they add about X DPS to attacks for 12 seconds after use. 180 DPS The Assassin (4th kill) 50 Cells

Tactics Mutations[]

Name Image Description Base Effects Blueprint Acquisition Method Unlock Cost
Efficiency -X% reduction of skill cooldowns 30% reduction N/A (Always available) N/A
Support About +X DPS while close to a deployed skill 45 DPS Inquisitor (100% chance) 50
Parting Gift Enemies drop a bomb dealing about X damage when killed without using hand to hand weapons. 65 damage Graveyard 50
Concentration About +X DPS while no enemies are nearby. 65 DPS Incomplete One (4th kill) 50
Brutal Recovery Hitting an enemy in melee with a projectile stuck in it removes the projectile, dealing about X damage. 60 damage Promenade of the Condemned 50

Efficiency's scaling with Tactics is given in the following table:

Tactics Level 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Cooldown Reduction 30% ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Survival Mutations[]

Name Image Description Base Effects Blueprint Acquisition Method Unlock Cost
Necromancy(?) +X HP when you kill an enemy. 2 HP N/A (Always available) N/A
Offensive Parry The next attack after a successful parry deals +X damage. 130 damage The Watcher (3rd kill) 50
Defensive Parry +X HP on a successful parry. 8 HP Ugly Worm (100% chance) 50
Extended Healing Your flasks now heal over 15 seconds but grant +X DPS during this time. 80 DPS Ossuary 50
Gastronomy(?) Eating food grants +X DPS for 30 seconds. Healing from food is increased by 200%. 50 DPS The Watcher (4th kill) 50

General Mutations[]

Note: the YOLO mutation is only obtainable immediately after the Prisoners' Cells. If its effect triggers, the mutation is removed, allowing for another mutation to be chosen.

Name Image Description Blueprint Acquisition Method Unlock Cost
Munitions x2 ranged weapon ammunition. N/A (Always available) N/A
Recovery The length of the rally effect is multiplied by 2. The Watcher (5th kill) 50
Quick Healing Speeds up flask usage by 300% and fully protects you for 5 seconds after use. The Assassin (6th kill) 50
Race The speed bonus from killing multiple enemies quickly lasts 2x longer. The Assassin (3rd kill) 50
Alienation Getting cursed restores 75% of max health. Curses require 2x fewer kills to lift. Incomplete One (5th kill) 50
Ygdar Orus Li Ox Saves you ONCE from death. N/A (Always available) N/A
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