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Pickups are items which are not gear, or runes. Pickups can be collected with the Interact command while the player is close or, in the case of gems, just by walking on top of them.

All main categories of pickups are:

  • Healing pickups that restore the player's health or reduce Malaise.
  • Scrolls to upgrade player stats.
  • Currency pickups, which award varying amounts of cells or gold.
  • Special pickups serving miscellaneous functions.
  • Keys, which let the player unlock doors.

Healing pickups

Food

Food regenerates a fixed percentage of health when eaten (or twice as much if the Gastronomy mutation is active). There are 2 different functional types of food, each with 7 different appearances depending on the selected diet, which is altered by game settings. If untouched by the player, it will be chosen as "Carnivore." Both types of food can add Malaise on Hell difficulty if the piece of food is infected. The amount of malaise given depends on if the food is major or minor. Minor food gives 50 points (1 bar) and major food gives 150 points (3 bars) of malaise. There will always be 2 clean pieces of food in any one biome, with one dropping from an enemy and another found in a wall rune. Any other drops, including those from lore rooms, will always be infected with Malaise on 4+ BSC.

Minor foods

Minor foods restore 15% of the player's maximum health (30% if Gastronomy Mutation IconGastronomy is active). They're dropped from enemies, wall and floor runes, and can be purchased from food shops with 0-3BSC active (with 4BSC+, food shops will sell a cough syrup instead).

Name Icon Diet setting
Kebab
Minor-carni-kebab-96x96
Carnivore
Carrot
Minor-vege-carrot-96x96
Vegetarian
Guts
Minor-mons-guts-96x96
Monster
Cherries
Minor-fruit-cherry-96x96
Fruitarian
Pastry
Minor-castle-cake-96x96
Castlevaniesque
"Le Croissant"
Minor-bag-croissant-96x96
Baguette
Small medkit
Smallmedkit
Half-Life
Gruyère
Minor-cheese-wedge
Cheese

Major foods

Major foods heal 50% of the player's maximum health (100% if Gastronomy Mutation IconGastronomy is active). They're found in the same ways minor foods are, as well as in lore rooms, but are rarer.

Name Icon Diet setting
Drumstick
Major-carni-chicken-96x96
Carnivore
Big ol' radish
Major-vege-radish-96x96
Vegetarian
Monster's Eye
Major-mons-monstereye-96x96
Monster
Watermelon
Major-fruit-watermelon-96x96
Fruitarian
Turkey
Major-castle-turkey-96x96
Castlevaniesque
"La Baguette"
Major-bag-baguette-96x96
Baguette
Large medkit
Medkit
Half-Life
Camembert
Major-cheese-wheel
Cheese

Other healing items

These healing items are more uncommon than food and can usually only be encountered under certain conditions.

Type Icon Description Sources
Flask Recharge
Healing Potion 1 Icon
Restores 1 Health Flask charge.
Cough Syrup
Cough Syrup
Reduces your Malaise infection level by 30%.
  • Food Shops
  • Cannot appear if Malaise has been disabled.

Scrolls

Scrolls are items that increase the player's stats.

Name Icon Effect Sources
Scroll of Power
Power
Adds one point to one of the three stats.
  • Scroll vats
  • Enemy drops
  • Cursed chest
  • Challenge Rift chest
Assassin's Scroll
Str Skill
Adds one point to either Brutality or Tactics.
  • Scroll vats
  • Enemy drops
Minotaur's Scroll
Str Hp
Adds one point to either Brutality or Survival.
Guardian's Scroll
Skill Hp
Adds one point to either Tactics or Survival.
Epic Scrolls of Power
EpicPower
Adds one point to all three stats.
Scroll Fragment
Scroll Fragments
Each 4th fragment collected will give a Scroll of Power.
  • Scroll Fragment pedestals
  • Enemy drops
  • Bosses
  • Scroll Fragments can only be found while 3 or more Boss Stem Cells are active.

Currency pickups

Gold centered

Gold is the main currency used for making purchases and weapon upgrades throughout runs. All enemies will drop small amounts of gold when killed that appears as tiny, bright pebbles that automatically fly towards the player to be collected.

Gems

Gems give a significant amount of gold when collected. Each one awards a different amount of gold depending on its type.

Gems in order of value
Name Icon Description Value Sources
Gold Tooth
Golden Tooth Icon
A tooth worth 100 GOLD. He was asking for it... 100
Golden Arrow
Golden Arrow Icon
A transmuted arrow worth 100 GOLD. When you care enough to shoot the very best. 100
Shiny Rock
Shiny Rock Icon
Totally and utterly worthless. You're not gonna pick that thing up, are you? 100
  • Guaranteed drop from one of the Key Dark Tracker Elites in High Peak Castle
  • Timed door reward
  • Wall runes (uncommon)
  • Random drop from enemies
Malachite
Malachite Icon
Quite common, but you shouldn't have any trouble getting 250 GOLD for it. 250
  • Wall runes (common)
  • Timed door reward
  • The Concierge death reward
  • Random drop from enemies
Amethyst
Amethyst Icon
This pretty stone will fetch you 500 GOLD! My precccioussss... 500
  • Wall runes (uncommon)
  • The Concierge death reward
  • Timed door reward
  • Random drop from enemies
Blue Sapphire
Blue Sapphire Icon
A magnificent stone worth 1000 GOLD! 1000
  • Wall runes (rare)
  • Timed door reward (rare)
  • Behind one of the 8 doors at the end of the Ancient Sewers.
Ruby
Ruby Icon
A precious stone of truly exceptional purity that will fetch you the modest sum of 1500 GOLD! 1500
  • Wall rune (very rare)
  • Cursed chest reward
  • Tutorial Knight's corpse on 4th run of a save in the Prisoner's Quarters (guaranteed drop)
Corrupted Artifact
Corrupted Artefact Icon
This is worth 10000 GOLD, but if you pick it up, you'll be cursed. (20-kill curse) 10000
  • Random drop from enemies
Fragment of the Philosopher's Stone
Philosophers Stone Icon
You're officially the richest creature on the island. This absolutely perfect little jewel is worth 75000 GOLD! 75000
  • Random drop from enemies (0.2%)
  • Wall runes (incredibly rare)

Dead Man’s Bag

Dead Man's Bag

A bag that spawns at the start of Prisoners' Quarters. It contains some of the gold from your last run. The value depends on your current level of Gold Reserves and any gold above this limit is lost.

Cells

centered

Cells are a special currency that is used primarily for unlocking items and upgrades. They are often dropped from slain enemies and bosses, or found in chests and canisters in biomes. Cells are lost upon death.

Cells can be spent in two ways; unlocking items and upgrades from The Collector, or by increasing the chance for higher quality gear to appear in runs from The Blacksmith.

Liposuction

Liposuction

A rare pickup that produces one extra cell on every kill for 45 seconds, even if an enemy normally can't drop any (Myopic CrowsFF, etc). The drop chance is 0.3%. The extra cells are gold instead of blue.

Residual cells

Residual Cells

A bag that spawns next to the Dead Man's Bag if you defeated the Hand of the King. It contains any cells possessed upon reaching the Throne Room, as well as the 40 cells dropped by the Hand of the King. If not picked up, or if the run is reset, the cells will be lost.

Other pickups

Bonus Point Stars

Main article: Bonus Point Stars

Bonus Point Star

Bonus Point Stars are exclusively found in the Daily Run. They give a 5-point bonus for each enemy killed for 15 seconds.

Secret Potion of ???

Keys

Unlike most pickups, keys are not used when they are picked up. Instead, they are added to the player's inventory, so they can be used later to open their respective doors. Keys remain in the player's inventory for the rest of the run if not used on the appropriate door and unused keys disappear upon death or at the end of a successful run.

The keys stop spawning if the respective Blueprints they are guarding have been obtained and turned in to the Collector.

Name Icon Location Notes
Gardener's Key
Gardener's Key
Promenade of the Condemned 3 Gardener's Keys are required to obtain the Explosive Crossbow IconExplosive Crossbow blueprint.
  • The first key requires the Ram Rune IconRam Rune
  • The second needs the Spider Rune IconSpider Rune or the Homunculus Rune IconHomunculus Rune
  • The third can be obtained by stomping a hidden flower in the ground three times.

After the Explosive Crossbow blueprint is collected, there will be Malachite or Amethyst gems in its place on subsequent runs as well as a random weapon or skill. The doors will also be permanently open.

In the Ramparts, the Graveyard, and the Forgotten Sepulcher, there is a secret room with a door unlocked by a Gardener's KeyGardener's Key, behind which is a Moonflower KeyMoonflower Key.

Iron Cells Key
Iron Cells Key
Prison Depths, Corrupted Prison Dropped by enemies inside the biome. Used to open 1 of 2 cell doors at the end of the biome, which grants the player a random item on an altar. Only 1 may spawn each run.
Old Service Key
Old Service Key
Ancient Sewers 3 Old Service Keys are dropped by enemies in the Ancient Sewers and are used to open any of the 8 doors at the end of the biome.

It stinks.

Village Key
Village Key
Stilt Village 2 Village Keys open doors further in the level. The mid-stage door can be bypassed with the Spider Rune IconSpider Rune, but the doors blocking the Clock Tower and Forgotten Sepulcher cannot be bypassed. A secret area in the village requires this key to unlock access to its prize, the blueprint for the Parry Shield IconParry Shield.
Clockmaker's Key
Clockmaker's Key
Clock Tower Opens the door blocking the exit to the Clock Room.
Bell Tower Key
Bell Tower Key
Clock Tower Drops from a Clock Tower bell when all 4 are rung in ascending order of the pitch of their ring[1]. Opens the door blocking the blueprint for Punishment IconPunishment.
Graveyard Key
Graveyard Key
Graveyard Opens the door leading into the underground portion of the graveyard.

Open the gates of Hell...

Architect's Key
Architect's Key
Graveyard (inside a wall rune) Opens the door blocking the blueprints for Merchandise Categories and Parting Gift Mutation IconParting Gift.
Crypt Key
Crypt Key
Forgotten Sepulcher 2 Crypt Keys are found throughout the biome, each letting player progress further in the level. They are all in rooms which can only be accessed with the Teleportation Rune IconTeleportation Rune.

2 Additional keys can be found if the player does not have the Explorer's Rune IconExplorer's Rune, which are dropped by 2 Elite Dark Trackers and used to unlock the doors leading to the rune. Once the rune is collected these keys won't appear again.

It seems to be very old.

Moonflower Key
Moonflower Key
Ramparts, Graveyard, Forgotten Sepulcher There are 3 Moonflower Keys:

Each appears in a secret room reached with a well-hidden passage through the walls. A glimpse of the room may hint at the passage's location, which is faintly marked by vines. Inside each room is a door requiring a Gardener's Key from the Promenade of the Condemned to pick up to the Moonflower Key. Reaching all four of these locations in a single run requires having 3 active BSC and passing through the 3-cell door leading from the Ramparts to the Insufferable Crypt. If all Moonflower Keys are collected, they can access a secret room in High Peak Castle hidden in a similar way as the rooms containing the keys. The room contains the blueprint for Acceptance Mutation IconAcceptance.

Castle Key
Castle Key
High Peak Castle There are 3 Castle Keys in High Peak Castle. They drop from the Elite enemies inside the colored doors. Only 2 are needed to proceed to the Throne Room, but the last grants access to a room where the player can find a Scroll of Power, 2 weapons, and the blueprint for the Boomerang IconBoomerang.
Cavern KeyRotG
Cavern Key
Prisoners' Quarters (inside the break in the wall at the entrance of the level) Opens the door to the CavernRotG in the Graveyard.

Once unlocked, the door remains open for future runs. Otherwise, the key will continue to respawn.

Garland KeyRotG
Garland Key
CavernRotG (in a ceiling secret space) Gives access to a gate in one 4 BSC door, which contains the blueprint of Festive Outfit.
Dilapidated Arboretum KeyTBS
Dilapidated Arboretum Key
Prisoners' Quarters (near entrance to Dilapidated ArboretumTBS from the deceased Royal Gardener) Opens the door to the Dilapidated ArboretumTBS. Once unlocked, the door despawns from future runs, unless the player doesn't have the DLC.
Distillery Key
Distillery Key
Derelict Distillery (behind a wall that needs to be broken with an explosive barrel) Opens the door to the exit of the biome.
Exclamation
[Show spoilers]
Allen KeyRotG
Contains spoilers
Allen Key
AstrolabRotG Dropped by an Elite Slammer. Used to open the door to the final section of the biome.
Exclamation
[Show spoilers]
Elevator KeyRotG
Contains spoilers
Elevator Key
AstrolabRotG Dropped by an Elite Failed Experiment. Opens the door to the elevator at the end of the biome.
Exclamation
[Show spoilers]
Guardian's KeyRotG
Contains spoilers
Guardian's Key
AstrolabRotG Dropped by two Elite Slammers at the end of the final section of the biome. Used to open 2 doors blocking access to the Observatory.
Exclamation
[Show spoilers]
Apex KeyRotG
Contains spoilers
Apex Key
AstrolabRotG Found in a secret area, at the end of an obstacle course. Used to open the door to the button that lets the blueprint for Sonic Carbine IconSonic Carbine drop.

Removed pickups

Removed healing items

Type Icon Description Sources
Small Cough Syrup
Small Cough Syrup
Reduces your Malaise infection level by 1%.
  • Elites (with Extended Healing Mutation IconExtended Healing)
  • No longer obtainable after v2.1, the Malaise Update.

Removed gems

Name Icon Description Value Sources
Golden Cell
Golden Cell Icon
A little gold cell worth 20 GOLD. 20 One per Cell while an amulet with the "Get gold as well as a cell" affix was equipped.

With v1.9, the Update of Plenty, this affix was removed, rendering this gem inaccessible.

Removed keys

Name Icon Location Notes
Fool Key Ossuary, Ancient Sewers Dropped from an Elite Zombie and an Elite Inquisitor that spawned from a Christmas present which also gave the player a 5-kill curse.

This key was later removed from the game and was only replaced in the Ancient Sewers with the Old Service Key.

Gold Cells Key
Gold Cells Key
Prison Depths Dropped by enemies inside the biome. Used to open a cell door at the end of the biome, which grant the player one Scroll.

With v1.5, the Corrupted Update, they were removed in place of a Cursed Chest at the beginning of this biome, which gives one Scroll of Power.

References

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